Research in nonhuman primates is opening the possibility of testing treatments for the early stages of Alzheimer鈥檚 and similar diseases, before extensive brain cell death and dementia set in. June 21 in Alzheimer鈥檚 & Dementia: The Journal of the Alzheimer鈥檚 Association shows up to a six-month window in which disease progress could be tracked and treatments tested in rhesus macaques.
鈥淭his is a very powerful translational model to test interventions that target the tau protein,鈥 said John H. Morrison, professor of neurology at the University of California, Davis, and , and corresponding author on the paper.
The tau protein is found in neurons in the brain. The spread of misfolded tau through the brain is implicated in Alzheimer鈥檚 disease, frontotemporal dementia and other dementias. In Alzheimer鈥檚, misfolded tau disrupts multiple processes essential for normal brain cell functioning. As the misfolded proteins spread, they affect neurons throughout the connected regions of cortex that are crucial for memory and cognition.
The sick neurons then cause an inflammatory response mediated early on by microglial cells. Eventually, neurons die, leaving neurofibrillary tangles of tau protein, one of the key markers of Alzheimer鈥檚 and other dementing illnesses.
Thanks to advances in brain imaging, the discovery of biomarkers in human serum and cerebrospinal fluid, and work in rodent models, we now know more about the early stages of Alzheimer鈥檚. But it is still difficult to figure out how tau, inflammation and disease progression relate to each other.
The macaque model bridges the gap between what we can learn from mouse models and from human patients, said 新澳门六合彩内幕信息 Davis postdoctoral researcher Danielle Beckman, first author on the paper.
Six months of measurable disease progression
The researchers injected a vector carrying DNA for two mutated tau proteins into the entorhinal cortex of 12 monkeys. The entorhinal cortex is a key brain region that is involved with memory and is where the disease usually originates in human Alzheimer鈥檚.
Over six months, they followed the spread of tau protein, affected cells and inflammation through the animals鈥 brains using PET and MRI imaging, biomarkers and by microscopy.
鈥淲e can see tau pathology on neurons, and we can trace all the steps over a few months as the pathology spreads,鈥 Beckman said.
The results show that in this model, there is a window of at least two to six months where the progress of the disease can be measured. That opens the possibility of preclinical testing of interventions that target the tau protein.
鈥淲e can look at drugs targeting early-stage Alzheimer鈥檚 before dementia develops,鈥 Morrison said. 鈥淚t鈥檚 all about early intervention to arrest progression.鈥
The paper builds on earlier work at the CNPRC establishing the nonhuman primate model. In future work, the researchers plan to combine the tau model with their existing model system based on amyloid.
Additional authors on the study are: Giovanne Diniz, Sean Ott, Brad Hobson and Abhijit Chaudhari at 新澳门六合彩内幕信息 Davis; Scott Muller, Yaping Chu and Jeffrey Kordower, Arizona State University; Akihiro Takano, Adam Schwarz, Chien-Lin Yeh, Paul McQuade, Maria Quinton and Arthur Simen, Takeda Development Center Americas Inc., Lexington, Mass.; Paramita Chakrabarty, University of Florida; Nicholas Kanaan, Michigan State University.
The work was funded by Takeda Pharmaceutical Company and grants from the NIH.
Media Resources
(Open Access)
Media Contacts:
- John Morrison, California National Primate Research Center, jhmorrison@ucdavis.edu
- Danielle Beckman, California National Primate Research Center, dbeckman@ucdavis.edu
- Andy Fell, News and Media Relations, 530-304-8888, ahfell@ucdavis.edu