新澳门六合彩内幕信息

Personalized Medicine for Cats With Heart Disease

Study Finds Genetic Makeup Influences Response to Common Feline Heart Disease Medication

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Cat with HCM sits on top of a notebook
新澳门六合彩内幕信息 Davis veterinarians identified Lizard, the cat pictured above, as having hypertrophic cardiomyopathy, a heart disease that affects 1 in 7 cats. He was part of the study examining how a cat鈥檚 DNA alters how it responds to a commonly prescribed medication to prevent blood clots in cats with HCM. (新澳门六合彩内幕信息 Davis School of Veterinary Medicine)

Veterinarians at the University of California, Davis, have found that a cat鈥檚 DNA alters how it responds to a life-saving medication used to treat hypertrophic cardiomyopathy, or HCM, a heart disease that affects 1 in 7 cats. The was published in the Nature Portfolio journal, Scientific Reports.

HCM causes a cat鈥檚 heart muscle to thicken. As the condition worsens, cats can form blood clots in their hearts that may later dislodge and cause extreme pain, distress and even sudden death. Clopidogrel, or Plavix庐, is one of the most commonly prescribed medications used to prevent blood clots in cats with HCM.

鈥淲e were consistently seeing cats that despite being on clopidogrel, were still forming blood clots,鈥 said corresponding author Josh Stern, professor of veterinary cardiology and geneticist with the 新澳门六合彩内幕信息 Davis School of Veterinary Medicine. This led Stern and the research team to begin research in this area and identify mutations in the drug pathway that looked important. Data showed that nearly 20% of cats had resistance to the clopidogrel therapy, which is widely used by practitioners all over the world.

鈥淭his study was about figuring out why some cats weren鈥檛 responding as expected to clopidogrel therapy and leading us towards a more effective prescription,鈥 Stern said.  

Simple genetic test

Researchers began a clinical trial on cats with HCM. They first tested the cats鈥 ability to form blood clots. The cats鈥 owners administered clopidogrel for 14 days, and the cats were tested again. Researchers were then able to test whether genetic mutations that they had identified within the drug pathway were responsible for reducing the drug鈥檚 effectiveness.

鈥淭he end result is the ability to use a simple genetic test to make an educated decision about which drug therapy may be best for preventing blood clots in cats with HCM,鈥 Stern said.

While testing like this is not yet commercially available, researchers hope that eventually veterinarians will be able to rapidly test cats with HCM for these mutations as they are making prescribing decisions.

鈥淲e are very excited to be approaching this era where personalized or precision medicine in animals can catch up to precision medicine in humans,鈥 said co-author Ronald Li, an assistant professor of veterinary emergency and critical care and coagulation researcher, whose lab conducted much of the functional testing of the anticoagulant therapies. 鈥淛ust as we can鈥檛 expect every human to respond to medication in the same way, we can鈥檛 expect all cats to respond the same way either.鈥

Researchers are hoping that in the future, personalized medicine for cats would allow veterinarians to test kittens for a whole host of genetic variants that would help inform medical decisions and treatments as they grow and require veterinary care.

Stern and the Cardiology Service at 新澳门六合彩内幕信息 Davis Veterinary Medical Teaching Hospital continue to offer clinical trials aimed at optimizing treatment for cats with HCM. The team has a current of a drug aiming to be the first veterinary drug to reverse this devastating disease.

The research was performed jointly by the Comparative Platelet and Neutrophil Physiology Laboratory and the Translational Cardiac Genetics and Pharmacogenomics Laboratory that are both housed within the Center for Companion Animal Health. Co-authors of this also include Karen Vernau, Nghi Nguyen, Maureen Oldach, Eric Ontiveros and Samantha Kovacs of 新澳门六合彩内幕信息 Davis School of Veterinary Medicine; Yu Ueda of North Carolina State University; and Michael Court of Washington State University. Funding was provided by the Morris Animal Foundation to support the research and graduate student education.

Media Resources

Media Contacts:

  • Josh Stern, 新澳门六合彩内幕信息 Davis School of Veterinary Medicine, jstern@ucdavis.edu
  • Ron Li, 新澳门六合彩内幕信息 Davis School of Veterinary Medicine, rhli@ucdavis.edu
  • Amy Quinton, 新澳门六合彩内幕信息 Davis News and Media Relations, amquinton@ucdavis.edu, cell-530-601-8077

 

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